Effect of Sunitinib Combined with Ionizing Radiation on Endothelial Cells
نویسندگان
چکیده
منابع مشابه
Effect of ionizing radiation on human skeletal muscle precursor cells
BACKGROUND Long term effects of different doses of ionizing radiation on human skeletal muscle myoblast proliferation, cytokine signalling and stress response capacity were studied in primary cell cultures. MATERIALS AND METHODS Human skeletal muscle myoblasts obtained from muscle biopsies were cultured and irradiated with a Darpac 2000 X-ray unit at doses of 4, 6 and 8 Gy. Acute effects of r...
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OBJECTIVE A number of studies have revealed that stress signaling and subsequent stress responses in stem/progenitor cells are responsible for attenuated regeneration or degenerative disease. Because ionizing radiation (IR), which sensitizes diverse types of stem cells, reportedly induces cardio-circulatory diseases, we hypothesized that IR-induced vascular abnormalities are associated with def...
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BACKGROUND Endothelial cells (EC) in tumor and normal tissue constitute critical radiotherapy targets. MicroRNAs have emerged as master switchers of the cellular transcriptome. Here, we seek to investigate the role of miRNAs in primary human dermal microvascular endothelial cells (HDMEC) after ionizing radiation. METHODS The microRNA status in HDMEC after 2 Gy radiation treatment was measured...
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Introduction: Today ionizing radiation (IR) plays an important role in medicine, both in diagnostic and therapeutic field. Doctors, medical staff and patients are all in danger of side effects of IR so there is a need to protect them against deleterious effects of ionizing radiation. Thymus vulgaris has biological activities like antioxidant and antibacterial activity. Aim of...
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The human vasculature is critical to healthy functioning of the tissues of the body and a major factor in maintaining homeostasis is the endothelial barrier. In the brain, the blood–brain barrier (BBB) is highly specialized in order to sustain the neural tissue. Here, we have examined the effects of radiation on BBB models using a unique variety of endpoints to assess barrier function. These in...
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ژورنال
عنوان ژورنال: Journal of Radiation Research
سال: 2011
ISSN: 0449-3060,1349-9157
DOI: 10.1269/jrr.10013